Invitro ADMET

Invitro ADMET

With undesirable ADME properties frequently prompting clinical failure and toxicity being the real explanation behind the attrition of endorsed drugs, it is essential to comprehend the metabolism and safety profiles of your compounds from the get-go in the disclosure procedure. In vitro facilities at Acubiosys give ADME (absorption, distribution, metabolism, excretion) services to provide quicker, and enhanced central decision-making points for our Chemistry clients or standalone offering to help tranquilizer discovery programs. We offer cost-effective institutionalized and modified examines according to the customer’s prerequisite for ADME parameters. The form of reporting can be tuned to meet your objectives; from small and exact spreadsheet to a full detail report with suggestions for future examinations.

OUR RESEARCH
  • Solubility
  • PAMPA Permeability(Gut, Brain, Skin)
  •  Log D
  • Metabolic Clearance
  • CYP Inhibition
  • Stability Studies
  • CYP Inhibition LC/MS/MS
  • Cell-Based Permeability
  • Efflux Transporter studies
  • Uptake Transporter studies
  • Metabolite Identification
  • Plasma protein Binding
  • Cytotoxicity
  • Genotoxicity
  • Identification Reactive Metabolite (GSH Trapping)
  • Time-dependent Inhibition
  • Metabolic Clearance
  • CYP Inhibition
  • Stability Studies
  • CYP-Inhibition
  • CYP-Induction
  • CYP-Phenotyping
  • Species comparison of Metabolic pathway