Invivo Pharmacokinetics
Invivo Pharmacokinetics
Invivo pharmacokinetic (PK) studies are a critical part of the medication advancement process. Knowing how the body retains, distributes, processes and kills drugs helps manage the dosing regimen to amplify adequacy and evade unwanted impacts. Acubiosys has established conventions to deal with a wide cluster of PK study designs. We have a goal of accomplishing a fast turnaround with quality outcomes for a sensible expense. Combined with results from in vitro ADME screens, in vivo PK information empowers the early identification of compound liabilities. This gives a premise to basic changes, or for the quick improvement of procedures to overcome these issues. We also offer a range of mechanistic studies to portray singular procedures that reinforce the pharmacokinetic profile of drug candidates. Our services for the in vivo evaluation for the compound PK properties include:
Our Research
- Study design using various model species
- Single, multiple, and cassette dose PK
- In vivo crossover studies for bioavailability (F)
- Various administration routes (i.v., p.o., i.p., s.c., i.m., etc.)
- Jugular vein, Femoral Vein Cannulation
- Serial blood collection over 24 hours
- Allometric dose prediction and PK optimization
- Effects of food, gender, and formulation type
- PK tissue distribution and mass balance
- Bile Excretion Studies
- Non-GLP toxicology (single dose, single dose escalating, repeat dose)
- TK/MTD (Toxicokinetics/maximum tolerated dose)
- Tail Vein Blood Collection (Rat/Mouse)
- Dog PK/Crossover Studies for bioavailability(F)
- Monkey PK Studies